| S/N | Name of Research Center | Year of Establishment | Missions | Managing College/Faculty/Institute |
| 1 | Dabat Research Center | 1996 | Create platform for research and academic excellence in public health and produce evidences for policy implications | College of Medicine, Health Sciences and Specialized Hospital |
| 2 | Climate Change Research Center | 2012 | Support, coordinate and mobilize climate change related research activities focusing on climate change adaptation and mitigation strategies at University level | Research &Publication Directorate |
| 3 | Tropical and Infectious Diseases Research Center | 2014 | Coordinate, facilitate and produced evidences for practical implementation and policy implications in the area of tropical and infectious diseases | College of Medicine, Health Sciences and Specialized Hospital |
| 4
5. | Non-Communicable Diseases Treatment & Research Center
Leishmaniasis Research and Treatment Center | 2004
2015 | Contribute on reducing avoidable non-communicable diseases and related public health problems
Promoting research on Leishmaniasis and serve as a treatment center and on clinical trials associated with visceral Leishmaniasis | College of Medicine, Health Sciences and Specialized Hospital
College of Medicine, Health Sciences and Specialized Hospital |
| 6 | Agricultural Research Centers | 2010 | Conduct, coordinate and facilitate participatory, agro-ecology and faming systems based agricultural research. | College of Agriculture and Rural Transformation |
| 7 | Social Science and Humanities Research Center | 2012 | Undertake societal problems solving research activities related to social science and humanities | College of Social Sciences and Humanities |
| 8 | Economic Policy and Analysis Research Center | 2016 | Produce research based evidences on policy research to foster economic growth | College of Business and Economics |
| 9 | Nanotechnology Research Center | 2016 | Conduct and Support Nano Sciences and Nano Technology awareness, education, research, development, design and engineering and technology transfer to industrial sector. | Research and Publication Directorate in collaboration with University- Industry Linkage & TT Directorate |
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